Epas1 CLIA Kit for Rat(Rattus norvegicus) | EIAab.comEpas1 CLIA Kit for Rat(Rattus norvegicus)

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Epas1 (Gene name),

Endothelial PAS domain-containing protein 1 (Protein name ), EPAS1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Epas1(Hif2a);

Protein name:

Endothelial PAS domain-containing protein 1(EPAS-1);

Alternative:

Hypoxia-inducible factor 2-alpha(HIF-2-alpha;HIF2-alpha);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerizes with ARNT.

Function:

Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

874

Sequence:

50:

100:

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300:

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850:

874:

NVPEPGSSTL | LQGRDLLRAL | DQAT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10116.ENSRNOP00000033874

KEGG:

rno:29452

UniGene:

Rn.163791

Pfam:

PF11413

UniGene:

Rn.55138

String:

Q9JHS1

SMR:

Q9JHS1

Uniprot:

Q9JHS1

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ELISA Kit for Rat EPAS-1

Cat.:

E2004h

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Packing:

96T

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ELISA Kit for Rat EPAS-1

Cat.:

E2004m

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96T

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ELISA Kit for Rat EPAS-1

Cat.:

E2004r

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Packing:

96T

CLIA Kit for Rat EPAS-1

Cat.:

U2004m

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MSDS:

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Packing:

96T

CLIA Kit for Rat EPAS-1

Cat.:

U2004h

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MSDS:

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Packing:

96T

CLIA Kit for Rat EPAS-1

Cat.:

U2004r

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Packing:

96T

Polyclonal Antibody for Rat EPAS-1

Cat.:

P2004Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat EPAS-1

Cat.:

P2004Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat EPAS-1

Cat.:

P2004Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat EPAS-1

Protein for Rat EPAS-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Perivenous expression of the mRNA of the three hypoxia-inducible factor a-subunits HIF-1a, HIF2a and HIF3a in rat liver."
Kietzmann T. , Cornesse Y. , Brechtel K. , Modaressi S. , Jungermann K.
Biochem. J.354:531-537(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Liver.

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